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Reviews

"In this fascinating and innovative book, Hogan describes the history of the 'physical map' of the human genome. His interlocked stories neatly illustrate the passage from very partial and crude visualization of human chromosomes to sophisticated genomic technologies of the twenty-first century while maintaining a focus on the chromosomes as the material frame of understanding genetic pathologies."

"How do we know what our genes tell us? In rich detail, Andrew Hogan reveals the technical, social, epistemological, cartographic, and clinical work that has produced our modern understandings of genetic medicine. In doing so he uncovers the challenges and limitations of our increasing reliance on genetic data in medical decision making."

"With historical depth and analytical rigor, Hogan traces the development of a twenty-first century genomic gaze that incorporates clinical knowledge, molecular biology, and the durable iconography of human chromosomes. Focusing on several genetic conditions that can be detected prenatally, he deftly connects modern clinical genetics to questions of disease etiology and prevention that have far-reaching ethical and societal implications."

"This engaging book tells a story we’ve been missing from the history of biomedicine. Hogan brings to life the micro-geography of chromosomes, and those who know them intimately as work objects. This intricate account of genetic syndromes in-the-making shows the continuing relevance of cytogenetic scaffolding to contemporary genomics."

"By presenting a historical review of the critical scientific literature for these clinical examples, the narrative provides an excellent demonstration of the sequential, developmental process of scientific discovery and acceptance of disease mechanisms... Recomended."

"Life Histories meticulously traces how the one mutation–one disease ideal has transformed clinical perception in recent decades—but it does so without ceding the primacy of a clinical thought-style to a molecular one. The book effectively shows that contemporary medicine’s embrace of genetic medicine has been a piecemeal development with more continuity across the decades than we have been conditioned to believe."

"Hogan paints his picture through an impressively detailed and engaging reconstruction of how it is that physicians and geneticists in the postwar period came to define genetic diseases, correlate them with particular genetic abnormalities, and detect and visualise these abnormalities in patients in the context of prenatal diagnostics. With"

"Deft analysis of visual practices and careful unpacking of the scientific literature make for an engaging read. This fresh alternative to the well-worn heroic narratives of gene sequencing and molecular genetics should be of particular interest to scholars of disability."

"Life Histories of Genetic Disease is a well-crafted historical journey exploring the research undertaken into the complex world of genetic disease and heredity... The book is a corpus of historical and scientific detective work, facts and breakthroughs, as well as quotations, metaphors and theories, and is written with purpose and clarity... This book is a great read, with wide appeal, including to anyone interested in medical history, as well as to students and those contemplating a career in the field of medicine and genetics."